Nov 3, 2006 · ERp27 was shown to bind Delta-somatostatin, the standard test peptide for protein disulfide isomerase-substrate binding, and this ability was ...
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ERp27 was shown to bind Δ-somatostatin, the standard test peptide for protein disulfide isomerase-substrate binding, and this ability was localized to the ...
The Crystal Structure of the Protein-Disulfide Isomerase Family ...
www.ncbi.nlm.nih.gov › PMC3548509
In this study, we present and analyze the crystal structure of ERp27, which contains the structural features needed for substrate binding in a fashion similar ...
Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates (PubMed:16940051, PubMed:23192347).
Aug 7, 2014 · The b' domain contains a large multivalent hydrophobic surface allowing for a structurally promiscuous binding site (Denisov et al., 2009). In ...
The b′ domain provides the principal peptide‐binding site of protein disulfide isomerase but all domains contribute to binding of misfolded proteins. Peter ...
PDI has two binding sites for BPA, the a and b′ domains, and ligands must interact with b′ for the inhibition of PDI activity to occur (Hashimoto, S., Okada, K.
Aug 14, 2022 · The b′ domain provides the principal peptide-binding site of protein disulfide isomerase but all domains contribute to binding of misfolded ...
Sep 9, 2015 · The peptide-binding mode observed in the crystal structure with NMR validation, was characterized by hydrophobic interactions on the b′ domain ...
1998 published a paper characterizing the misfolded protein and peptide binding domains of human PDI. The authors found that the human PDI b′ domain is ...